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Sulfates are the major circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The key oxidative metabolite is two-hydroxy ethinyl estradiol, fashioned by the CYP3A4 isoform of cytochrome P450. Part of the 1st-move metabolism of ethinyl estradiol is considered to manifest in gastrointestinal mucosa. Ethinyl estradiol may